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Epinephrine in Neonatal Resuscitation

Apr 02, 2019 · 1. Introduction. The infrequent need for chest compressions and epinephrine use during neonatal resuscitation [1,2], coupled with an inability to consistently anticipate which newborns are at high risk of requiring extensive resuscitation, explains the ongoing lack of high quality evidence supported by large randomized clinical trials to better guide healthcare …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518253/ 

The Route, Dose, and Interval of Epinephrine for Neonatal

Oct 01, 2020 · Asphyxia is a leading cause of neonatal death and disability worldwide, and some of these deaths may be preventable by improvements in neonatal resuscitation. 1 Epinephrine (adrenaline) is recommended as a key medication in neonates who have not responded to previous resuscitation measures, including lung ventilation and chest compressions 2 ; …

https://publications.aap.org/pediatrics/article/146/4/e20200586/79685/The-Route-Dose-and-Interval-of-Epinephrine-for 

What is the optimal initial dose of epinephrine during

The neonatal resuscitation program recommends a wide dose range of epinephrine for newborns who receive chest compressions (endotracheal tube [ET] dose of 0.05-0.1 mg/kg or intravenous [IV] dose of 0.01-0.03 mg/kg), which presents a challenge to neonatal care providers when attempting to determine the optimal initial dose.

https://pubmed.ncbi.nlm.nih.gov/33712718/ 

Why does the NRP state the dosage of epinephrine as mL/kg

Why does the NRP state the dosage of epinephrine as mL/kg instead of mg/kg? Dosing epinephrine in the newborn presents unique patient safety risks. Epinephrine is very infrequently used during neonatal resuscitation and many health providers have little experience preparing or administering epinephrine in an emergency.

http://aap.helpjuice.com/46971-nrp-general-information/224710-why-does-the-nrp-state-the-dosage-of-epinephrine-as-ml-kg-instead-of-mg-kg 

Epinephrine for Neonatal Resuscitation: The Limits of

Oct 01, 2020 · Epinephrine (from the Greek epi-nephros, “on top of the kidneys”), known across the Atlantic pond as adrenalin (from the Latin ad-renal, “near the kidneys”), has been an unquestioned staple in the neonatal resuscitation drug toolkit for many decades. First extracted from the adrenal medulla in 1895, purified in 1901, and synthesized in 1904, this drug has …

https://publications.aap.org/pediatrics/article/146/4/e2020019968/79654/Epinephrine-for-Neonatal-Resuscitation-The-Limits 

NRP Epinephrine Update - OPQIC

May 11, 2017 · NRP Epinephrine Update. From the NRP: As of May 1, 2016, the U.S. Pharmacopeia (USP) and FDA no longer allowed drug manufacturers to use ratio expressions on any epinephrine container labels except for local anesthetics with epinephrine. So, as inventory of the old epinephrine packaging is depleted, the former 1:1,000 and 1:10,000 ratio

https://opqic.org/nrp-epinephrine-update/ 

What is the optimal initial dose of epinephrine during

Mar 12, 2021 · The neonatal resuscitation program recommends a wide dose range of epinephrine for newborns who receive chest compressions (endotracheal tube [ET] dose of 0.05–0.1 mg/kg or intravenous [IV] dose

https://www.nature.com/articles/s41372-021-01032-7 

NEW NRP 2017 GUIDELINES - UCLA Health

2017 NRP Major Changes Positive-Pressure Ventilation: After completing the initial steps, PPV is indicated if a newborn is apneic or gasping or the heart rate is less than 100 beats/m Once PPV initiated – Adjust flowmeter to 10 L/min. If PPV is required for resuscitation of a preterm newborn, it is preferable to use a device that can provide PEEP.

https://www.uclahealth.org/nursing/workfiles/Education%20Courses/ContinuingEducation/6NewNRP-2017Guidelines_Skills%20Dayv2.pdf